I. Immediate treatment for datura poisoning:

a) Airway clearance
b) Ensuring breathing
c) Maintenance of circulation

II. General reatment for datura poisoning:

a) Prevention of absorption and also elimination of poison
i) Removal of clothing
ii) Skin wash with soap water
iii) Stomach wash with weak solution of KMnO4 or water
vi) Whole bowel irrigation
vii) Haemoperfusion
b) Supportive management
i) Aspiration of secretions
ii) O2 therapy
iii) IV infusion
iv) Artificial ventilation if needed
c) Inactivation of the absorbed poison
Antagonist: Inj. Physostigmine or Pilocarpine 1.4 mg in adult
e) Symptomatic treatment of datura poisoning
i) Cold sponging for hyperpyrexia
i) Antipyretics
iii) Antibiotics to prevent infection
iv) Anticonvulsant e.g. Inj. Diazepam 10 mg I.M. start
f) Maintenance of nutrition– oral (if possible) or parenteral
g) Follow up of the patient to prevent any complication of datura poisoning.