|Written by Dr.Md.Redwanul Huq (Masum)|
|Monday, 16 January 2012 12:56|
Protein-energy malnutrition (PEM) consists of a wide range of clinical conditions occurring in infants and young children due to lack of protein and/or energy or both and associated with infection.
Classification of Protein-energy malnutrition (PEM):
Classification of Protein-energy malnutrition (PEM) is as following:
* Gomez classification (wt for age):
|Grade of PEM||Weight for age (%)|
|Mild malnutrition, Grade I||75-89|
|Moderate malnutrition, Grade II||60-74|
|Severe malnutrition, Grade III||Less than 60|
* Water low classification:
|Grade of PEM||Stunting (low height for age)||Wasting (low wt for height)|
|Severe malnutrition||Less than 80||Less than 70|
* Welcome classification:
|Weight for age||With edema||Without edema|
|Less than 60%||Marasmic kwashiorkor||Marasmus|
Differences between Kwashiorkor and Marasmus are given below:
|Cause||Mainly due to Calorie deficiency||Mainly due to protein deficiency|
|Time of onset||Onset is earlier, usually in first year of life||Onset is later, usually after breast feeding is stopped|
|Growth failure||More marked||Not very prominent|
|Edema||No edema||Edema present|
|Blood protein concentration||Reduced less noticeably||Reduced very much|
|Skin changes||Less frequent||Red boils and patches are typical symptoms|
|Liver infiltration with fat||Not infiltrated||Infiltrated|
|Recovery period||Prolonged in marasmus||Small in kwashiorkor|
Risk factors of PEM:
i) Socioeconomic factors – poverty, lack of parental awareness and education
ii) Feeding practices – introduction of formula, easy cessation of breast feeding, non- exclusive breastfeeding, insufficient complementary feeding practices
iii) Infections – water contamination and diarrhea are associated with PEM, malnutrition adversely affect the immune status and make the malnourished child more vulnerable to infections, during infections the child’s appetite is impaired. Moreover, wrong practices of withholding food, reducing feeding or diluting infant formula during the episodes of diarrhea may lead to PEM.
iv) Maternal factors – short maternal stature, anemia, low pre-pregnancy weight appear to be major factors in producing LBW babies who are more likely to develop PEM. Less birth space and large family size may also contribute to the poor nutritional status of mother.
Management of PEM (Protein energy malnutrition):
- Hb or PCV
- Blood glucose
- S. electrolytes
- Serum protein
- Urine R/M/E & C/S
- Stool R/M/E
- Chest X-RAY
- Skin test for TB (MT)
- Test for HIV.
Possible findings in PEM:
In case of kwashiorkor:
- Low levels of insulin and insulin like growth factor
- High levels of plasma cortisol and growth hormone
- Depletion of S. electrolytes, especially potassium and magnesium
- Decreased urinary excretion of urea
- LDH- Decreased
- Low levels of circulating lipids
Increased urinary 3-methylhistidine
In both kwashiorkor and marasmus:
- Iron deficiency anemia
- Metabolic acidosis
- False-negative tuberculin skin test.
- Decreased urinary excretion of hydroxyproline
Treatment of protein energy malnutrition:
Treatment of protein energy malnutrition (PEM) is divided into 3 phases:
1. Initial treatment / resuscitation (For one week)
2. Rehabilitation (For 2 – 6 weeks)
3. Follow up (Upto 3 years).
1. Initial treatment:
The objectives are as follows:
* To treat or prevent hypoglycemia
* To treat or prevent hypothermia
* To treat or prevent dehydration
* To restore electrolyte balance
* To treat incipient or developed septic shock, if present
* To start to feed the child
* To treat infection
* To identify and treat vitamin deficiencies, severe anaemia and heart failure.
i) Treatment of hypoglycemia-
|Blood glucose (mmol / L)||Condition of the child||Treatment|
|Less than 3 mmol/L or 54 mg/dl||Alert||50 ml bolus of 10% glucose or sucrose (Oral / NG)|
|Less than 3 mmol/L||Lethargic, unconscious or having convulsion||5 mg/Kg body weight 10% glucose I/V then50 ml bolus of 10% glucose or sucrose (Oral / NG)|
ii) Treatment of hypothermia-
* Keeping the baby warm by wrapping with clothes, blankets, caps and socks
* Appropriate feeding.
iii) Treatment of dehydration-
Intravenous rehydration: It is indicated in-
1. Malnourished child with circulatory collapse
2. Child with septic shock
1. Ringer’s Lactate solution with 5% glucose
2. 0.45% normal saline with 5% glucose
3. Half strength Darrow’s solution with 5% glucose
* I/V solution : 15 ml/Kg/hour I/V for 2 hours +
10 ml/ Kg/hour for 10 hours with ReSoMal orally or through NG feeding.
Feeding during rehydration :
* Breast feeding
* F – 75 diet after 2 – 3 hours of rehydration.
iv) Treatment of Septic shock:
* I/V rehydration and oral / NG feeding
* Blood / plasma transfusion -10ml/Kg body weight slowly over 3 hours.
* Inj: Vitamin K 1 -1 mg I/M single dose.
v) Dietary treatment:
* NG tube feeding- interval : 1st day 2 hourly and from 2nd day 4 hourly, day and night
* Diet : F-75(75 Kcal/100ml)
* Fluid : Chart of F-75 Diet(100ml/Kg/day)
* Calorie: Not less than80 Kcal/Kg/day(100ml/Kg/day) and not more than 100 Kcal/Kg/day.
* Preparation of F-75 and F-100 Diets:
|Ingredients||F-75 Diet||F-100 Diet|
|Skimmed milk powder||25 g||80 g|
|Sugar||70 g||50 g|
|Cereal flour||35 g||–|
|Vegetable oil||27 g||60 g|
|Mineral mix||20 ml||20 ml|
|Vitamin mix||140 mg||140 mg|
|Water to make||1000 ml||1000ml|
vi) Treatment of infection:
1.For severely malnourished children choice of antibiotics are-
* Benzyl penicillin
* Best combination is [C-penicillin + Gentamycin] or, [Ampicillin + Gentamycin].
2. For amboebiasis and Giardiasis- choice is Metronidazole.
3. For dysentery choice is Nalidixic acid.
4. For helminthiasis the choices are-
- Albendazle – 400 mg once
- Mebendazole – 100 mg twice daily for 3 days
- Pyrantel pamoate – 1 mg /Kg single dose
5. For tuberculosis the drugs are-
6. For malaria-
* For P. vivax, P. malariae and P. ovale – Cloroquine
* For P. falciparum malaria:
- Pyrimethamine + Sulfadoxine
7. For measles
* For Candida infection in diaper area-
- Nystatin ointment or cream (100000 IU) bd for 2 weeks
- Oral nystatin (100,000 IU qds)
* For other affected areas:
- Castor oil ointment
- 1% potassium permanganate
- Povidone iodine
- Petroleum jelly
- Paraffin gauge dressing.
vii) Treatment of vitamin deficiency:
* Treatment of clinically vitamin A deficiency children-
|Timing||Age of the child||Dosage|
|Day 1||Less than 6 months||50,000 IU|
|6 – 12 months||1,00,000 IU|
|More than 12 months||2,00,000 IU|
|Day 2||Same age specific dose|
|2 weeks later||Same age specific dose|
* Ocular inflammation or ulceration:
– Application of eye pads soaked in 0.9% saline
– Tetracycline eye drops (1%)
– Atropine eye drops (0.1%).
viii) Treatment of severe anemia:
Blood transfusion (10ml/Kg over 3 hours)
– If Hemoglobin is less than 40 gm/L or PCV is less than 12%.
ix) Treatment of congestive heart failure:
* All oral intake and I/V fluid are stopped
* Diuretics: Frusemide (1mg/Kg)
* Digitalis (Digoxin).
x) Treatment of mineral deficiency:
* KCl : 3-5 mEq/kg/day for 2 weeks (1 tsf = 10 mEq)
* MgSO4: 10 mg/kg/day 2 weeks
* Zinc: 2 mg/Kg/day for 2-3 weeks(1 tsf = 50 mEq).
* Iron: 3 mg/Kg/day in 2 divided doses for 3 months.
Criteria for transfer to a nutrition rehabilitation centre:
* Eating well
* Sits, crawls, stands or walks
* Normal temperature
* Improved mental state
* No edema
* No vomiting
* No diarrhea
* Gaining weight – more than 5 gm/kg/day for 3 consecutive days.
* Less than 2 years-
– Liquid or semi-liquid fluid
– F- 100 diet- every 4 hours, night and day, increasing amount of diet at each feed by 10 ml until child refuses to finish the feed
– Calorie- 120-220 Kcal/kg/day
* More than 2 years-
– F-100 diet and solid food
– F-100 diet and mixed diet- alternatively 6 times daily.
Stimulation of emotional & sensorial development:
- Environment facilities
- Playing facilities
- Physical activities.
Vaccination to the child if not yet taken.
Criteria for discharge:
A child with PEM should continue to be followed up in the nutrition clinic until the following criteria are fulfilled:
- Weight-for-age of the child increases to above -2SD for three consecutive visits.
- The child is gaining weight at a normal or an increased rate.
- The child can eat the recommended amounts of nutritious foods at the frequency and nutritional quality recommended.
- The child is not pale and has been given the required doses of vitamins and minerals.
- The child is not suffering from any apparent illness or infection.
- Mother is able to carry out the feeding recommendations, manage minor health problems at home and she knows when to seek medical advice.
- Health worker is capable to communicate with the Community Support Group members in the community and ensure follow up of the child.
3. Follow Up:
* 1st Follow up- After 7 days
* 2nd Follow up- After 30 days
* 3rd Follow up- After 3 months
* 4th Follow up- After 6 months
* Next Follow up- Twice yearly for at least 3 years.
Complications of PEM:
* Electrolyte imbalance.