Clinical features of datura poisoning:

1. Drowsiness
2. Delusion
3. Delirium
4. Dilatation of pupils
5. Dryness of mouth
6. Dryness of throat
7. Dimness of vision
8. Dysphagia
9. Dry and hot skin, hyperpyrexia
10. Distended of bladder due to retention of urine
11. Distended abdomen,
12. Dysarthria
13. Nausea, vomiting
14. Retention of faeces
15. Staggering gait
16. Pill rolling movement
17. Convulsion
18. Stupor
19. Coma.

Management of datura poisoning:

I. Immediate management:

a) Airway clearance
b) Ensuring breathing
c) Maintenance of circulation

II. General measurements:

a) Prevention of absorption and also elimination of poison

i) Removal of clothing
ii) Skin wash with soap water
iii) Stomach wash with weak solution of KMnO4 or water
vi) Whole bowel irrigation
vii) Haemoperfusion

b) Supportive management

i) Aspiration of secretions
ii) O2 therapy
iii) IV infusion
iv) Artificial ventilation if needed

c) Inactivation of the absorbed poison

Antagonist: Inj. Physostigmine or Pilocarpine 1.4 mg in adult

e) Symptomatic treatment of datura poisoning

i) Cold sponging for hyperpyrexia
i) Antipyretics
iii) Antibiotics to prevent infection
iv) Anticonvulsant e.g. Inj. Diazepam 10 mg I.M. start

f) Maintenance of nutrition– oral (if possible) or parenteral

g) Follow up of the patient to prevent any complication.